Positive – A positive result for this test indicates that the patient has inherited a mutation in the BRCA1 or BRCA2 genes, and therefore she has a higher risk of suffering from breast and ovarian cancer. The risk in women carrying mutations increases between 3 and 7 times in comparison to women who do not have any mutation. However, it is important to note that a positive result does not always mean that the patient will develop cancer in 100% of the cases, neither it determine when she will suffer it.
Biological children of a person (male or female) who has a mutation in one of these two genes will have a 50% chance of inheriting the mutation, independently of whether or not their parents end up developing cancer.
Negative – A negative result for this test means that the person does not have a pathogenic mutation in none of the two genes and therefore they will no transmit it to their offspring. This person will have the same risk of developing breast and ovarian cancer as anyone in the general population.
If the person who undergo the test has a positive familiar history that suggests the possibility of having a hereditary genetic mutation, but the complete genetic test has not identified any mutation in the BRCA1 and BRCA2 genes in the family, a negative result is less clear. It is possible that they carry a mutation in another gene different to BRCA1 and BRCA2.
Sample type: 5ml peripheral blood in EDTA
PTC Laboratories Thailand only provides testing and does not provide any genetic counselling. The patient must seek the advice of a genetic counsellor to get guidance on reading and interpreting the report.